SSRIs and anticoagulants . . . and other stories
BMJ 2024; 385 doi: https://doi.org/10.1136/bmj.q884 (Published 25 April 2024) Cite this as: BMJ 2024;385:q884
Selective serotonin reuptake inhibitors and oral anticoagulants
SSRIs are among the most frequently prescribed antidepressants, at least in part because of their favourable safety profile. However, serotoninergic mechanisms are involved in haemostasis, and the potential adverse effects of these drugs may have been underestimated. A study used a UK primary care database to compare the risk of major bleeding in people already taking SSRIs who were starting oral anticoagulants because of atrial fibrillation with controls using oral anticoagulants alone. Risk of bleeding increased by 33% in the first few months for people taking both SSRIs and oral anticoagulants (JAMA Netw Open doi:10.1001/jamanetworkopen.2024.3208).
Mixed connective tissue disease
A retrospective study in France which reviewed 300 patients who fulfilled criteria …
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