Letters
Acute painful crisis in adults with sickle cell disease
Author’s reply to Wolf
BMJ 2025; 388 doi: https://doi.org/10.1136/bmj.r45 (Published 10 January 2025) Cite this as: BMJ 2025;388:r45
- Kenneth S Charles, senior lecturer and consultant haematologist
- University of the West Indies, St Augustine, Trinidad and Tobago
- kenneth.charles{at}sta.uwi.edu
I agree with Wolf’s concerns about transfusion in sickle cell disease.12 In developed countries, where the blood donor pool is predominantly white and lacking the Ro antigen, transfusion for sickle cell disease is often affected by alloantibody formation, which complicates future transfusions. Iron overload is a potential complication of chronic blood transfusions in …
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