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Rapid responses are electronic comments to the editor. They enable our users to debate issues raised in articles published on bmj.com. A rapid response is first posted online. If you need the URL (web address) of an individual response, simply click on the response headline and copy the URL from the browser window. A proportion of responses will, after editing, be published online and in the print journal as letters, which are indexed in PubMed. Rapid responses are not indexed in PubMed and they are not journal articles. The BMJ reserves the right to remove responses which are being wilfully misrepresented as published articles or when it is brought to our attention that a response spreads misinformation.

From March 2022, the word limit for rapid responses will be 600 words not including references and author details. We will no longer post responses that exceed this limit.

The word limit for letters selected from posted responses remains 300 words.

Re: Resolution of peanut allergy: case-control studyScience commentary: Why do some children grow out of peanut allergy? Jonathan O'B Hourihane, Abi Berger, Stephen A Roberts, John O Warner. 316:doi 10.1136/bmj.316.7140.1271

Dear Sirs

I read your recent article in the BMJ with regard infants growing out of a Peanut Allergy with interest. I am the father of a 21 month old boy who had an attack from such an allergy when he was 13 months old, when he exhibited three of the symptoms you mentioned a rash, facial swelling and tightness of the throat. However, he has had no further exposure to nuts since then and hence no further reactions.

He has recently had a blood test which indicated an allergy to mixed nuts at level three, however we are finding it hard to find out what this actually means, the extent of his allergy, e.g. life threatening or not ,and if he has or could grow out of it.

I would be very grateful if you could provide me with the details of who I might contact to find this out and / or any further relevant reading material.

Thank you for your help

Kind regards

Duncan Dunlop

Competing interests: No competing interests

27 April 1998
Duncan Dunlop
general manager
peterborough
Re: Statistics notes: Sample size in cluster randomisation Sally M Kerry, J Martin Bland. 316:doi 10.1136/bmj.316.7130.549

Sir,

I welcome the contribution of Kerry and Bland on cluster randomization (BMJ 1998; 316: 549). As long as our world contains more patients than doctors, this issue should be taken into account when planning a study.
The example they present, however, may be somewhat misleading. The proposed study addresses the effect of two interventions on cholesterol level. One is an intensive dietary intervention by practice nurses, the other is usual general practice care.
The data they use to estimate clustering are on cholesterol levels from a thrombosis prevention trial. It is unclear whether these are pre- or post-intervention data, but in both cases I doubt whether the magnitude of clustering of cholesterol concentrations in this study is a reliable estimate for the proposed study. I would not be surprised when the clustering in the practice nurse intervention would turn out to be much higher, as this may be much more affected by personal factors.

Johannes C van der Wouden
Department of General Practice
Erasmus University Rotterdam
PO Box 3000
1738 DR Rotterdam The Netherlands
email: vanderwouden@hag.fgg.eur.nl
fax + 31 10 436 07 17
tel + 31 10 408 76 11

Competing interests: No competing interests

26 April 1998
Johannes C van der Wouden
research coordinator
Dept of General Practice, Erasmus University Rotteram, The Netherlands
Re: Transferring medical images on the world wide web for emergency clinical management: a case report David S Johnson, Rajinder P Goel, Paul Birtwistle, Phil Hirst. 316:doi 10.1136/bmj.316.7136.988

Editor- Johnston et al1 report a system for transmitting medical
images across a system based on personal computers and the internet's
world wide web. The method described is clearly an effective approach for transmitting images of radiographs. However the adoption of this technique will require a significant investment in technology. Such an investment may simply not be affordable for many departments, particularly as it will often be smaller, peripheral units that do not have access to resident specialist advice.

Last year I worked in an A&E department that had no on-site orthopaedic service. A patient presented with a fracture of the lower radius, for which I sought advice from the orthopaedic registrar on-call in the specialist unit 30 miles away in Belfast. As he was unable to view the radiograph of the injury he was uncertain whether internal fixation would be required. Therefore he recommended that until the radiograph was available to them the following morning the patient should be admitted to our surgical ward overnight.

However after discussion we decided on a new approach. I was able to use a pen to trace the outline of the bones by placing a sheet of plain A4 paper over the film on the illuminated X-Ray box.. This provided an accurate drawn image of the fracture, which I then faxed (using the department fax machine) to my colleague in Belfast. Shortly afterwards he phoned me back to say that he could see from the faxed image that the fracture needed internal fixation. Therefore the patient was transferred immediately for this treatment.

I would commend this approach to other departments requiring advice on the management of fractures from non-resident specialists. This technique is simple, easily taught, and is unlikely to require any additional investment in new technology. As such it represents a ‘low-tech’ alternative to the technique described by Johnston et al in their article.

1 Transferring medical images on the world wide web for emergency clinical
management: a case report: David S Johnson BMJ 1998;316:988-989 ( 28 March )

Competing interests: No competing interests

26 April 1998
Martin Breach
GP Principal
Maghull, Merseyside
Re: Screening babies for hip dislocation is not effective Louise McKee. 316:doi 10.1136/bmj.316.7140.1261i

This article ends with the sentence: "In some European countries around 40 times the number of children who you would expect to develop a dislocation are being treated non-surgically."
What is missing is the "punch-line":
How many European children in those same countries are treated surgically, and how many of those treated surgically were "missed" (meaning the screening found a stable hip which afterwards became unstable and needed surgery) on the hip screening programs (which I am sure is also prevalent in those same countries - since I am sure the article meant the same countries where U/S and rediologic screening is done for these babies.
As a mother I would prefer unnecessary non-surgical treatment (also - no details were given for this either - premanipulation skin traction, closed reduction, fixation/immobilization in cast), if I knew that in 1 of 40 children this prevented later surgery (both short-term and long term, of course).

Competing interests: No competing interests

26 April 1998
Shoshi Band
Regulatory Affairs
TEVA Pharmaceuticals
Re: Developing http://www.bmj.com/ Tony Delamothe. 315:doi 10.1136/bmj.315.7122.1558

The team at Stanford University who collaborated with the BMJ on the implementation of the new BMJ web site is very pleased with the results on the screen, and is also very much encouraged by the feedback we have received from readers who have filled out the questionnaire on the site.

Generally, one could characterize the feedback in a single word, "more", or perhaps "MORE!". That is, readers like what they see and they want more back content online, and more future services.

This is, as you can imagine, music to a web-developer's ears, since people rarely ask for more of something they found useless in the first place (excepting collectors of cancelled stamps, I suppose).

We look forward to continuing our work, and hope the BMJ's readers will continue their comments.

Competing interests: No competing interests

25 April 1998
John Sack
Director
HighWire Press, Stanford University
Re: Feed your head Tony Delamothe. 316:doi 10.1136/bmj.316.7131.637a

It was certainly encouraging to see that doctors read a wide variety of very good books. The list could have appeared in the 'suggested readings' of most good general-purpose -- and certainly most university-based -- bookstores I visit.

Competing interests: No competing interests

25 April 1998
John Sack
Director
HighWire Press, Stanford University
Re: Adverse drug reactions Munir Pirmohamed, Alasdair M Breckenridge, Neil R Kitteringham, B Kevin Park. 316:doi 10.1136/bmj.316.7140.1295

I read the excellent article about ADRs by Pirmohamed.

It is common practice in Medicine to put patients on combinations of drugs. The vast majority of these combinations of drugs (especially where 3 or more drugs are involved) have never been studied at all, let alone in double-blind trials ( with the exception of Oncology/AIDS treatment, where the toxicity of the drugs demands study); yet it is frequent practice to prescribe these multiple-drug combinations.

It is well accepted in Pharmacology that it is scientifically
impossible to accurately predict the side effects or clinical effects of a
combination of drugs without studying that PARTICULAR
combination of drugs in TEST subjects. Knowledge of the pharmacologic profiles of the individual drugs in question does not in any way
assure accurate prediction of the side effects of combinations of those drugs, especially when they have different mechanisms of action, which is very common because polypharmacy is most often prescribed to patients with "multiple illnesses". Yearly, over 180,000 patients in this country die from identified adverse drug reactions; the number who die as a consequence of polypharmacy is, to my knowledge, unknown.

Is the use of unstudied polypharmacy an example of "scientific" Medicine?

The argument that the prescribing of drugs is the "Art of Medicine" is not valid,
because drugs are developed (indications, dose and administration, etc) and approved through a "scientific" process (double-blind, placebo-controlled studies). The fact that the medicines are often prescribed for "different conditions" is irrelevant (especially to the patient's physiology). The idea that " we are doing the best we can ", a frequent
defense of Polypharmacy, does not in any way uphold a scientific argument in favor of it.
(We are, indeed, trying the best we can, with tools which do not improve at the rate we would wish!) The fact that "there is a limit to how much research can be done" in no way makes the research unnecessary in order to predict the effects of specific combinations of drugs.

Parenthetically, non-conventional systems of health care are often condemned on the basis that they are
"unscientific" or "unstudied". Shouldn't those of us in conventional medicine look at our way of practicing using the same "scrutiny" with which we often condemn "alternative" systems of medicine?

Respectfully,

Charles Sullivan, D.O.

179 Main St suite 403

Waterville, ME
(207)877-0950

dorje@mint.net

"Science progresses, funeral by funeral." - Max Planck

Competing interests: No competing interests

25 April 1998
Charles Sullivan
Family Physician
Waterville, ME
Re: The dying adult Colin Murray Parkes. 316:doi 10.1136/bmj.316.7140.1313

Thank you for your excellent article on the dying adult. I
lost my Father two years ago, from prostate cancer, and reading your article brought back many of the hardships of his last four months of life. Many of the subjects you mentioned, especially the fear, were striking.

Our family was really unprepared for Dad's anxiety, as were the doctor and the pastor. We all had great expectations that his dying would be strong and a great example to us all. My greatest lesson of that time was learning to respect this time of dying as unique to the person. Dad's way of dying was his own, and as fearful as it was, it was his way and we learned to walk with him.

I think that perhaps families need to give up prior visions of their loved ones final days--hours in quiet conversation, dispensing wisdom, talking fondly of days gone by. Perhaps the dying person will indeed exhibit that sense of acceptance. But one must also be prepared for sudden anxiety attacks, crying jags, hopelessness, nightmares, fears of medication, refusal to eat, and other problems.

Thank you for talking about this. Doctors especially need to talk with families about how "it is going." It is so easy to rush on to the next patient. To be fair, our doctor was good, and also a friend of the family, which made it hard for him. But I give him great tribute for coming out to Dad's home on a regular basis and reasurring him regularly.

Sincerely,

Virginia B. Mulhern

*I found this article while searching the Net for a medical subject for a paper due in a class I'm taking.

Competing interests: No competing interests

25 April 1998
Virginia Mulhern
none
Public Health Medical Therapy
Re: Medical and psychosocial effects of early discharge after surgery for breast cancer: randomised trial Paul I M Schmitz, Marinus A Paul, Theo Wiggers, et al. 316:doi 10.1136/bmj.316.7140.1267

I was diagnosed with Paget's Disease and went through a radical mastectomy in January '98. My surgery was performed about 2 PM on the 14th and I was released at 9 AM on the 15th. only 18 hours later.

While I really didn't want a long hospital stay I feel that there was no time to adjust and your head is still in a whirl that what ever instructions you are give going home are not absorbed. If it had been a day or two later my head would have been clearer and I would have retained these instructions.

I did have problems with the drain getting plugged and homecare came out three times in one day to assist me in unplugging it. It was scary and upsetting being alone and not knowing exactly what was going on. After about four days things settled and I was fine. I had no problems with infections.

In my opinion I think a two to three day stay would be beneficial to the patient. My stay was far too short and may people just couldn't believe it was so short. I am not one to demand a great deal of attention but there are people who do and take up a lot of the staff time over minimal things.

Competing interests: No competing interests

25 April 1998
Sheila Whitlock
City of Edmonton

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