Sir,
I welcome the contribution of Kerry and Bland on cluster randomization (BMJ 1998; 316: 549). As long as our world contains more patients than doctors, this issue should be taken into account when planning a study.
The example they present, however, may be somewhat misleading. The proposed study addresses the effect of two interventions on cholesterol level. One is an intensive dietary intervention by practice nurses, the other is usual general practice care.
The data they use to estimate clustering are on cholesterol levels from a thrombosis prevention trial. It is unclear whether these are pre- or post-intervention data, but in both cases I doubt whether the magnitude of clustering of cholesterol concentrations in this study is a reliable estimate for the proposed study. I would not be surprised when the clustering in the practice nurse intervention would turn out to be much higher, as this may be much more affected by personal factors.
Johannes C van der Wouden
Department of General Practice
Erasmus University Rotterdam
PO Box 3000
1738 DR Rotterdam The Netherlands
email: vanderwouden@hag.fgg.eur.nl
fax + 31 10 436 07 17
tel + 31 10 408 76 11
Competing interests: No competing interests
confused parent
Dear Sirs
I read your recent article in the BMJ with regard infants growing out of a Peanut Allergy with interest. I am the father of a 21 month old boy who had an attack from such an allergy when he was 13 months old, when he exhibited three of the symptoms you mentioned a rash, facial swelling and tightness of the throat. However, he has had no further exposure to nuts since then and hence no further reactions.
He has recently had a blood test which indicated an allergy to mixed nuts at level three, however we are finding it hard to find out what this actually means, the extent of his allergy, e.g. life threatening or not ,and if he has or could grow out of it.
I would be very grateful if you could provide me with the details of who I might contact to find this out and / or any further relevant reading material.
Thank you for your help
Kind regards
Duncan Dunlop
Competing interests: No competing interests